Never give a shepherd an even break: class and labor among the Komachi

Never give up.

Sall4 won’t give stem cells a break

A protein that helps embryonic stem cells (ESCs) retain their identity also induces the cells to repair DNA damage, Xiong et al. report. Fixing broken DNA is particularly important for ESCs because they pass on any mutations to their differentiated descendants. Mouse ESCs are adept at making repairs—they carry far fewer mutations than do differentiated cells—but how they achieve this isn’t clea...

Immortal Strands? Give Me a Break

The "immortal strand" hypothesis proposes that asymmetrically dividing stem cells selectively retain chromosomes containing "old" DNA to prevent accumulation of mutations. As I describe in this Essay, such a possibility seems unlikely. An alternative explanation is that asymmetric cell divisions and cell fate are codirected by epigenetic differences between sister chromatids.

Fetal dendritic cells give mum a break.

A Study on the Organizational Output by Concluding Break Even-Point through the Application of Matlab Simulink Method

A strategy that integrates an organization's marketing goals into a cohesive whole, ideally drawn from market research, focuses on the ideal product mix in order to achieve maximum profit potential; the marketing strategy is set out as a marketing plan, a good idea, method, information, object, or service that is the end result of a process and serves as a need or want satisfier. It is usually ...